Two Distinct regions of the integumentary system epidermis & dermis É/–ü¼’â@dermis is vascularized True É/–ü¼’â@- localized change in color (freckle) Macule É/–ü¼’â@accumulated fluid in papillary layer (hives) Wheal É/–ü¼’â@solid elevated area, epidermal and papillary (insect bite) Papule É/–ü¼’â@large papules extending into subcutaneous layer (cyst) Nodule É/–ü¼’â@papule with fluid core (second degree burn) Vesicle É/–ü¼’â@papule with pus core (acne) Pustule É/–ü¼’â@- ruptured vesicle (ulcer) Erosion É/–ü¼’â@dry skin Xerosis É/–ü¼’â@benign tumor in the dermis (capillary and cavernous) Hemangiomas É/–ü¼’â@enlargement of the sebaceous gland Sebaceous hyperplasia É/–ü¼’â@- irritating itching sensation of the skin Seborrheic dermatitis É/–ü¼’â@- malignant cancer originating in the germinative layer Basal cell carcinoma É/–ü¼’â@- malignant cancer originating in the top layer of the skin Squamous cell carcinoma É/–ü¼’â@metastasizing melanocytes Malignant melanomas É/–ü¼’â@reddened skin, embarrassment, fever, hypertension, inflammation, or allergy Redness (erythmia) É/–ü¼’â@pale skin, emotional distress or anemia, low blood pressure Pallor/blanching É/–ü¼’â@- liver disease, bile deposited in tissue Jaundice É/–ü¼’â@- bronze coloration (addison's disease) hypofunction of adrenal cortex Bronzing É/–ü¼’â@- bruises, escaped blood clots in tissue spaces (clotted blood masses = hematomas) Black & blue - É/–ü¼’â@ É/–ü¼’â@